March 18, 2021 Thursday
We are entering the time frame projected to be the beginning of the fourth surge due to the coronavirus variants. Waiting to see changes in 7-day average data and staring at daily bar graph trends is painful. Stare long enough, and the graphs start dancing - thank you, brain‽
https://neurosciencenews.com/waterfall-illusion-brain-14138/
https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases
-----Latest Data---
CDC National Hospitalization trend data
https://covid.cdc.gov/covid-data-tracker/#hospitalizations
Global-View:
https://www.ft.com/content/a2901ce8-5eb7-4633-b89c-cbdf5b386938
Nationally:
https://ig.ft.com/coronavirus-chart/?areas=usa&areas=gbr&areasRegional=usny&areasRegional=usca&areasRegional=usfl&areasRegional=ustx&areasRegional=usco&cumulative=0&logScale=0&perMillion=1&values=casesf
The U.S. Regionally - N.Y. Times:
https://www.nytimes.com/interactive/2020/us/coronavirus-us-cases.html
Vaccine Tracker
https://covid.cdc.gov/covid-data-tracker/#vaccination-trends
-----
A recently coronavirus-exposed person contacted me yesterday asking about how much Vit D to use. I cannot emphasize enough that I have not seen convincing data on using vitamin D, zinc, vitamin C, ivermectin, HCQ, or any other therapy to:
-protect against post-exposure prophylaxis
-avoiding hospitalization
-avoiding intubation
-avoiding death
There are studies. They are often poorly designed and not well controlled. All that said, I do not feel comfortable recommending any of these therapies to my patients (what dose? how long? what indications? what contraindications? - all unknowns). Remember - Primum non nocere.
Here is what we know:
-For worsening and high-risk patients, monoclonal antibodies help minimize disease severity and progression. You can get this administered in various sites with a physician order (link below).
-Remdisivir may be beneficial in some hospitalized patients.
-Get vaccinated ASAP; stay masked and distanced.
https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html
https://protect-public.hhs.gov/pages/therapeutics-distribution#distribution-locations
While I am more critical of articles that make predictions based on models, one that offers me the confirmation bias of what I want to happen feels good. I hope these authors are correct about the coming weeks - "The course of the UK COVID 19 pandemic; no measurable impact of new variants."
https://www.medrxiv.org/content/10.1101/2021.03.16.21253534v1
Some European countries are seeing rising cases and deaths.
https://apnews.com/article/europe-coronavirus-surge-cautionary-tale-for-us-051e996d5b7e31711bb741e2f9ba724f
I am starting to see the historical records from the last year compiled. I find this timeline of insights awe-inspiring. Of course, it takes a pandemic to keep us focused at scale, but still.
https://www.nature.com/articles/s41577-021-00522-1
and
https://twitter.com/EricTopol/status/1332771238771630080
One more shared article from Eric Topol - highlighted and discussed
The article's data supports the need to vaccinate previously infected individuals and points toward the need for boosters in the fall.
https://twitter.com/EricTopol/status/1372329717928325125
Infographic of the day: What not to eat
Here is a fascinating set of data on the potentially lethal doses of a wide variety of things. Maybe my Coloradan friends can help me understand how much cannabis one would need to ingest to get 1270 mg of THC per Kg of body weight for a 100 Kg male. This method of poisoning seems expensive and inefficient.
https://ceufast.com/imgs/lethal-doses-55-subtances-4_comp.png
from
https://ceufast.com/blog/the-lethal-doses-of-55-substances
Bonus Round --- Calendar fun
March 20 is the spring Equinox. The roundup of how ancient civilizations marked these days made this worth the read:
https://www.livescience.com/what-is-an-equinox.html
Related, here are some solstice articles:
https://www.livescience.com/57280-winter-solstice-science-explained.html
and
https://www.livescience.com/62870-summer-solstice-animals.html
Clean hands and sharp minds, team
Adam
Back on Monday
We are entering the time frame projected to be the beginning of the fourth surge due to the coronavirus variants. Waiting to see changes in 7-day average data and staring at daily bar graph trends is painful. Stare long enough, and the graphs start dancing - thank you, brain‽
https://neurosciencenews.com/waterfall-illusion-brain-14138/
https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases
-----Latest Data---
CDC National Hospitalization trend data
https://covid.cdc.gov/covid-data-tracker/#hospitalizations
Global-View:
https://www.ft.com/content/a2901ce8-5eb7-4633-b89c-cbdf5b386938
Nationally:
https://ig.ft.com/coronavirus-chart/?areas=usa&areas=gbr&areasRegional=usny&areasRegional=usca&areasRegional=usfl&areasRegional=ustx&areasRegional=usco&cumulative=0&logScale=0&perMillion=1&values=casesf
The U.S. Regionally - N.Y. Times:
https://www.nytimes.com/interactive/2020/us/coronavirus-us-cases.html
Vaccine Tracker
https://covid.cdc.gov/covid-data-tracker/#vaccination-trends
-----
A recently coronavirus-exposed person contacted me yesterday asking about how much Vit D to use. I cannot emphasize enough that I have not seen convincing data on using vitamin D, zinc, vitamin C, ivermectin, HCQ, or any other therapy to:
-protect against post-exposure prophylaxis
-avoiding hospitalization
-avoiding intubation
-avoiding death
There are studies. They are often poorly designed and not well controlled. All that said, I do not feel comfortable recommending any of these therapies to my patients (what dose? how long? what indications? what contraindications? - all unknowns). Remember - Primum non nocere.
Here is what we know:
-For worsening and high-risk patients, monoclonal antibodies help minimize disease severity and progression. You can get this administered in various sites with a physician order (link below).
-Remdisivir may be beneficial in some hospitalized patients.
-Get vaccinated ASAP; stay masked and distanced.
https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html
https://protect-public.hhs.gov/pages/therapeutics-distribution#distribution-locations
While I am more critical of articles that make predictions based on models, one that offers me the confirmation bias of what I want to happen feels good. I hope these authors are correct about the coming weeks - "The course of the UK COVID 19 pandemic; no measurable impact of new variants."
https://www.medrxiv.org/content/10.1101/2021.03.16.21253534v1
Some European countries are seeing rising cases and deaths.
https://apnews.com/article/europe-coronavirus-surge-cautionary-tale-for-us-051e996d5b7e31711bb741e2f9ba724f
I am starting to see the historical records from the last year compiled. I find this timeline of insights awe-inspiring. Of course, it takes a pandemic to keep us focused at scale, but still.
https://www.nature.com/articles/s41577-021-00522-1
and
https://twitter.com/EricTopol/status/1332771238771630080
One more shared article from Eric Topol - highlighted and discussed
The article's data supports the need to vaccinate previously infected individuals and points toward the need for boosters in the fall.
https://twitter.com/EricTopol/status/1372329717928325125
Infographic of the day: What not to eat
Here is a fascinating set of data on the potentially lethal doses of a wide variety of things. Maybe my Coloradan friends can help me understand how much cannabis one would need to ingest to get 1270 mg of THC per Kg of body weight for a 100 Kg male. This method of poisoning seems expensive and inefficient.
https://ceufast.com/imgs/lethal-doses-55-subtances-4_comp.png
from
https://ceufast.com/blog/the-lethal-doses-of-55-substances
Bonus Round --- Calendar fun
March 20 is the spring Equinox. The roundup of how ancient civilizations marked these days made this worth the read:
https://www.livescience.com/what-is-an-equinox.html
Related, here are some solstice articles:
https://www.livescience.com/57280-winter-solstice-science-explained.html
and
https://www.livescience.com/62870-summer-solstice-animals.html
Clean hands and sharp minds, team
Adam
Back on Monday
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